AskDefine | Define thyroxin

Dictionary Definition

thyroxin n : hormone produced by the thyroid glands to regulate metabolism by controlling the rate of oxidation in cells; "thyroxine is 65% iodine" [syn: thyroxine, tetraiodothyronine, T]

Extensive Definition

Thyroxine, or 3,5,3',5'-tetra­iodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland.
T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin (TBG), and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.
Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3). T4 is converted in the tissues by deiodinases to T3. The "D" isomer is called "Dextrothyroxine" and is used as a lipid modifying agent. The half-life of thyroxine once released into the blood circulatory system is about 1 week.
The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger.

References

thyroxin in Arabic: ثيروكسين
thyroxin in Bulgarian: Тироксин
thyroxin in Czech: Thyroxin
thyroxin in Danish: Thyroxin
thyroxin in German: Thyroxin
thyroxin in Dhivehi: ތައިރޮކްސިން
thyroxin in Spanish: Tiroxina
thyroxin in Estonian: Türoksiin
thyroxin in Finnish: Tyroksiini
thyroxin in French: Thyroxine
thyroxin in Hebrew: תירוקסין
thyroxin in Italian: Tiroxina
thyroxin in Japanese: サイロキシン
thyroxin in Lithuanian: Tiroksinas
thyroxin in Dutch: Thyroxine
thyroxin in Polish: Tyroksyna
thyroxin in Portuguese: Tiroxina
thyroxin in Swedish: Tyroxin
thyroxin in Turkish: Tiroksin
thyroxin in Chinese: 甲狀腺素
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